Research

Our group's research interests are in the area of neuroscience, with a focus on neurodegeneration. Students assist in exploring a detailed understanding of the molecular and cellular mechanisms involved in protein aggregation and its role in neurodegenerative diseases. Protein aggregation is a common element associated with neurodegeneration as seen in Huntington's disease, amyotrophic lateral sclerosis (Lou Gehrig's disease), fronto-temporal dementia, Alzheimer's disease, and Parkinson's disease. We take advantage of biochemical and microscopy approaches to study in vitro and in vivo protein aggregation, using D. melanogaster and C. elegans transgenic model systems. More recently, we have begun exploring the intriguing possibility that long-lived trees, which have a more robust strategy in preventing protein aggregation, might provide important and valuable molecular clues, focusing on various tree hormones and small molecules, for mitigating the effects of neurodegeneration in humans.